Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.44 |
| ▸ | CCNK | O75909 | 7/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | CDK7 | P50613 | 4/20 | 0.42 |
| ▸ | CCNH | P51946 | 4/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128789 | 0.90 | CCNK (0.40) | EIF2AK2MAPK10CCNKCDK12CCNA2 | |
| SCHEMBL2180119 | 0.84 | MAPK10 (0.40) | EIF2AK2MAPK10CCNKCDK12CCNA2 | |
| SCHEMBL2678668 | 0.83 | ACHE (0.54) | KDM4EALDH1A1 | |
| SCHEMBL2179310 | 0.82 | MKNK1 (0.44) | EIF2AK2MAPK10CCNKCDK12CCNA2 | |
| SCHEMBL2178908 | 0.82 | EIF2AK2 (0.45) | EIF2AK2MAPK10CCNKCDK12CDK2 | |
| SCHEMBL2678012 | 0.80 | EIF2AK2 (0.42) | EIF2AK2MAPK10CCNA2CDK2GSK3B | |
| SCHEMBL2679483 | 0.76 | DYRK1A (0.54) | MAPK9MAPK14KDM4EMEN1KMT2A | |
| SCHEMBL6128569 | 0.75 | ACHE (0.52) | KDM4EALDH1A1 | |
| SCHEMBL2679965 | 0.75 | HDAC3 (0.44) | EIF2AK2MAPK9GSK3BKDR | |
| SCHEMBL2177054 | 0.74 | DYRK1A (0.43) | EIF2AK2MAPK10CCNKCDK12CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | claimed |
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |