Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MECP2 | P51608 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23593377 | 0.83 | MAPT (0.42) | MAPTKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL26783459 | 0.77 | MAPT (0.40) | MAPTKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL26783543 | 0.75 | KMT2A (0.38) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL29639853 | 0.73 | IDO1 (0.60) | MAPTRAB9ANPC1MAPK1CASP3 | |
| SCHEMBL23572579 | 0.73 | IDO1 (0.60) | MAPTRAB9ANPC1MAPK1CASP3 | |
| SCHEMBL26783488 | 0.69 | MAPT (0.44) | MAPTKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL23593416 | 0.66 | KDM4E (0.43) | MAPTKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL9545146 | 0.65 | TLR8 (0.58) | MAPTL3MBTL1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL28192482 | 0.64 | ALDH1A1 (0.60) | MAPTKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL12376784 | 0.62 | KMT2A (0.59) | MAPTKMT2AMEN1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810116-B1 | NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-11-15 | — | — | EP | disclosed |