Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | CASP1 | P29466 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957547 | 0.90 | KDM4E (0.67) | ADORA2AKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL26780528 | 0.85 | ADORA2A (0.73) | ADORA2AKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL429337 | 0.84 | ADORA2A (0.71) | ADORA2AKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL14955421 | 0.84 | ADORA2A (0.75) | ADORA2AKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL29707339 | 0.84 | KDM4E (0.70) | KDM4ESMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL3494383 | 0.84 | KDM4E (0.70) | KDM4ESMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL25808573 | 0.84 | KDM4E (0.65) | ADORA2AKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL22957447 | 0.82 | KDM4E (0.67) | KDM4ESMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL5858952 | 0.80 | KDM4E (0.64) | KDM4ESMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL3493480 | 0.79 | KDM4E (0.63) | KDM4ESMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | USP28, USP30, USP8 | ADORA2A 4728/4885KDM4E 1927/4885SMN1; SMN2 1921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.