Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 6/20 | 0.77 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.77 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.77 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.77 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.77 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.77 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.77 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.75 |
| ▸ | CDK2 | P24941 | 4/20 | 0.75 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.75 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM5A | P29375 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141305 | 0.80 | CCNA2 (1.00) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL17283670 | 0.78 | CCNA2 (0.69) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL6562826 | 0.76 | NPC1 (1.00) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL26784594 | 0.73 | HCAR3 (0.59) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL4314346 | 0.72 | CCNA2 (1.00) | CCNA2CDK2CCNA1 | |
| SCHEMBL6341557 | 0.71 | CCNA2 (0.85) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL6339700 | 0.71 | CCNA2 (0.82) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL1663611 | 0.71 | NPC1 (0.89) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL16654040 | 0.71 | NPC1 (0.60) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL21430743 | 0.70 | FGFR1 (0.67) | CCNA2CDK2CCNA1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814388-B1 | Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers | FERRIS STATE UNIVERSITY (US) | 2023-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11814388-B1 | Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers | AURKA, AURKC, AURKB | PRKAB2 1717/4885PRKAG1 1712/4885PRKAA2 1716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.