Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2678725 | 0.91 | MET (0.50) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2678537 | 0.88 | IGF1R (0.47) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2678312 | 0.88 | MET (0.47) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2678964 | 0.88 | MET (0.47) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2678661 | 0.86 | IGF1R (0.51) | METIGF1RCHRNB2CHRNA4KDM4E | |
| SCHEMBL2678341 | 0.86 | IGF1R (0.63) | METIGF1RAURKACCNA2CDK2 | |
| SCHEMBL2456511 | 0.85 | IGF1R (0.44) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2456510 | 0.84 | IGF1R (0.60) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2678542 | 0.83 | IGF1R (0.48) | METIGF1RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4285746 | 0.82 | AURKA (0.47) | IGF1RAURKACCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173659-B2 | Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-05-08 | — | — | US | disclosed |
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |