SCHEMBL26789846

SCHEMBL26789846

COC[C@H]1C[C@H](n2cc(I)c3c(N)ncnc32)CN1C(=O)OC(C)(C)C

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 18/20 0.63
▸ ADK P55263 2/20 0.48
▸ EGFR P00533 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30404376 1.00 SRC (0.63) SRCADKEGFR
SCHEMBL26791254 0.90 SRC (0.64) SRCEGFR
SCHEMBL30403393 0.89 SRC (0.52) SRCADK
SCHEMBL26789849 0.89 SRC (0.52) SRCADK
SCHEMBL31463180 0.86 SRC (0.58) SRCEGFR
SCHEMBL30035929 0.86 SRC (0.58) SRCEGFR
SCHEMBL15345656 0.85 SRC (0.63) SRCEGFR
SCHEMBL15345657 0.85 SRC (0.63) SRCEGFR
SCHEMBL26789839 0.85 ADK (0.48) SRCADK
SCHEMBL26806680 0.85 ADK (0.48) SRCADK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KINNATE BIOPHARMA INC. 2023-11-23 — — US disclosed
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KINNATE BIOPHARMA INC. 2023-11-23 — — US disclosed
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KINNATE BIOPHARMA INC. 2023-11-23 — — US disclosed
EP-4161657-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES Kinnate Biopharma Inc. (US) 2023-04-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES FGFR1, FGFR2, FGFR3 SRC 30/4885ADK 374/4885EGFR 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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