Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680067 | 1.00 | DGAT1 (0.41) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL7875234 | 0.93 | DGAT1 (0.42) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL2680252 | 0.93 | DGAT1 (0.34) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL2680249 | 0.93 | DGAT1 (0.34) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL2680325 | 0.91 | HSD17B10 (0.35) | DGAT1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL2680324 | 0.91 | HSD17B10 (0.35) | DGAT1ALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL2680917 | 0.90 | DGAT1 (0.40) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL2680922 | 0.90 | DGAT1 (0.40) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL2723620 | 0.89 | DGAT1 (0.43) | DGAT1MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL2679692 | 0.89 | DGAT1 (0.39) | DGAT1MTORRPTORMLST8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8591943-B2 | Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-11-26 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | DGAT1 3031/4885MTOR 1/4885RPTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.