⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633043 | 1.00 | — | — | |
| SCHEMBL24880069 | 1.00 | — | — | |
| SCHEMBL964997 | 0.84 | CACNA2D1 (0.56) | — | |
| SCHEMBL13286712 | 0.84 | ALDH1A1 (0.52) | — | |
| SCHEMBL28211141 | 0.81 | ALDH1A1 (0.50) | — | |
| SCHEMBL9945578 | 0.81 | ALDH1A1 (0.50) | — | |
| SCHEMBL4652961 | 0.81 | TSHR (0.39) | — | |
| SCHEMBL597708 | 0.81 | — | — | |
| SCHEMBL8171725 | 0.80 | — | — | |
| SCHEMBL5608034 | 0.80 | ALDH1A1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120475-A1 | 3-CYCLIC AMINE-INDOLE DERIVATIVES AS SEROTONERGIC AGENTS FOR THE TREATMENT OF CNS DISORDERS | MINDSET PHARMA INC. (CA) | 2022-06-16 | — | — | WO | disclosed |
| WO-2021155467-A1 | 3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS | MINDSET PHARMA INC. (CA) | 2021-08-12 | — | — | WO | disclosed |
| EP-3761036-A1 | PREGABALIN IMMUNOASSAYS | ARK Diagnostics, Inc. (US) | 2021-01-06 | — | — | EP | disclosed |
| EP-3265074-B1 | PREGABALIN IMMUNOASSAYS | ARK DIAGNOSTICS INC (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10023885-B2 | Process for the preparation of pregabalin | HIKAL LIMITED (IN) | 2018-07-17 | — | — | US | disclosed |
| US-9745249-B2 | Method for the preparation of beta-substituted gamma-amino carboxylic acids | SIEGFRIED LTD. (CH) | 2017-08-29 | — | — | US | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-20170114003-A1 | METHOD FOR THE PREPARATION OF BETA-SUBSTITUTED GAMMA-AMINO CARBOXYLIC ACIDS | SIEGFRIED LTD. (CH) | 2017-04-27 | — | — | US | disclosed |
| US-20150344919-A1 | PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2015-12-03 | — | — | US | disclosed |
| US-8134023-B2 | Preparation of pregabalin and related compounds | PFIZER INC (US) | 2012-03-13 | — | — | US | disclosed |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2011-03-17 | — | — | US | disclosed |
| WO-2010115612-A2 | PREGABALIN COMPOSITIONS | SYNTHON B.V. (NL) | 2010-10-14 | — | — | WO | disclosed |
| US-7763749-B2 | Method for the preparation of Pregabalin and salts thereof | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2010-07-27 | — | — | US | disclosed |
| US-20090312560-A1 | PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR | SYNTHON BV (NL) | 2009-12-17 | — | — | US | disclosed |
| EP-1745136-B1 | METHOD FOR ENZYMATIC PREPARATION OF (S)-3-CYANO-5-METHYLHEXANOIC ACID | PFIZER PROD INC (US) | 2009-10-07 | — | — | EP | disclosed |
| WO-2009087674-A2 | IMPROVED PROCESS FOR THE PREPARATION OF (S)-PREGABALIN | Watson Pharma Private Limited (IN) | 2009-07-16 | — | — | WO | disclosed |
| US-20080188562-A1 | 1-{[ alpha -isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid and 3-{[( alpha -isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-methyl hexanoic acid; extended oral release dosage form with a reduced rate of systemic clearance and without significant side effects | XENOPORT, INC. | 2008-08-07 | — | — | US | disclosed |
| US-20070073085-A1 | Method for the preparation of pregabalin and salts thereof | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-29 | — | — | US | disclosed |
| WO-2006122258-A1 | METHOD FOR THE PREPARATION OF PREGABALIN AND SALTS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006110783-A2 | PROCESS FOR MAKING (S)-PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-10-19 | — | — | WO | disclosed |