Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.64 |
| ▸ | MET | P08581 | 20/20 | 0.64 |
| ▸ | KDR | P35968 | 18/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798096 | 0.87 | IGF1R (0.83) | IGF1RMETKDR | |
| SCHEMBL783502 | 0.85 | MET (0.76) | IGF1RMETKDR | |
| SCHEMBL199328 | 0.78 | IGF1R (1.00) | IGF1RMETKDR | |
| SCHEMBL798838 | 0.77 | MET (0.80) | IGF1RMETKDR | |
| SCHEMBL198025 | 0.76 | IGF1R (1.00) | IGF1RMETKDR | |
| SCHEMBL197786 | 0.75 | IGF1R (1.00) | IGF1RMETKDR | |
| SCHEMBL200741 | 0.75 | IGF1R (1.00) | IGF1RMETKDR | |
| SCHEMBL200876 | 0.74 | MET (1.00) | IGF1RMETKDR | |
| SCHEMBL199399 | 0.74 | IGF1R (1.00) | IGF1RMETKDR | |
| SCHEMBL198072 | 0.74 | IGF1R (1.00) | IGF1RMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |