Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 8/20 | 0.34 |
| ▸ | RAD52 | P43351 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | BUB1B | O60566 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310087 | 0.91 | ALDH1A1 (0.37) | MAP4K1BRD4RAD52SMN1; SMN2KMT2A | |
| SCHEMBL26810055 | 0.91 | ALDH1A1 (0.37) | MAP4K1BRD4RAD52SMN1; SMN2KMT2A | |
| SCHEMBL29566685 | 0.91 | ALDH1A1 (0.37) | MAP4K1BRD4RAD52SMN1; SMN2KMT2A | |
| SCHEMBL26810000 | 0.90 | MAP4K1 (0.41) | MAP4K1BRD4RAD52BUB1BJAK2 | |
| SCHEMBL29567227 | 0.90 | MAP4K1 (0.43) | MAP4K1BRD4RAD52BUB1BJAK2 | |
| SCHEMBL24310343 | 0.90 | MAP4K1 (0.43) | MAP4K1BRD4RAD52BUB1BJAK2 | |
| SCHEMBL24310545 | 0.88 | KMT2A (0.38) | BRD4MEN1KMT2AHSD17B10TSHR | |
| SCHEMBL26812314 | 0.87 | KMT2A (0.40) | SMN1; SMN2MEN1POLBKMT2AHSD17B10 | |
| SCHEMBL26809994 | 0.87 | GUSB (0.36) | BRD4PIM1FLT3JAK3 | |
| SCHEMBL24310583 | 0.87 | RIPK2 (0.38) | MAP4K1BRD4FLT3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | MAP4K1 3678/4885BRD4 1716/4885RAD52 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.