Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.68 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.68 |
| ▸ | STAT3 | P40763 | 4/20 | 0.56 |
| ▸ | GRAMD1A | Q96CP6 | 6/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | CASK | O14936 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26813134 | 0.99 | CRBN (0.68) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26826535 | 0.99 | CRBN (0.70) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26831913 | 0.98 | CRBN (0.68) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26814640 | 0.98 | CRBN (0.69) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26812712 | 0.98 | CRBN (0.69) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26814675 | 0.98 | CRBN (0.69) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26829959 | 0.97 | CRBN (0.68) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26831262 | 0.97 | CRBN (0.66) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26813090 | 0.96 | CRBN (0.68) | CRBNDDB1STAT3GRAMD1ACA2 | |
| SCHEMBL26813031 | 0.95 | CRBN (0.68) | CRBNDDB1STAT3GRAMD1ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833208-B2 | PLK1 selective degradation inducing compound | UPPTHERA, INC. (KR) | 2023-12-05 | — | — | US | disclosed |
| US-20230372498-A1 | PLK1 SELECTIVE DEGRADATION INDUCING COMPOUND | UPPTHERA (KR) | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230372498-A1 | PLK1 SELECTIVE DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | CRBN 1386/4885DDB1 328/4885STAT3 2097/4885 |
| US-11833208-B2 | PLK1 selective degradation inducing compound | PLK1, BUB1B, BUB1 | CRBN 1386/4885DDB1 328/4885STAT3 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.