Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26814517 | 0.92 | SMN1; SMN2 (0.38) | MAP4K1TSHRSMN1; SMN2PIK3CDPIK3CB | |
| SCHEMBL26814696 | 0.90 | MTOR (0.36) | MAP4K1TSHRSMN1; SMN2PIK3CDPIK3CB | |
| SCHEMBL26814683 | 0.90 | MKNK1 (0.38) | MAP4K1TSHRSMN1; SMN2PIK3CDPIK3CB | |
| SCHEMBL26806466 | 0.90 | HTR1A (0.34) | MAP4K1TSHRSMN1; SMN2PIK3CDPIK3CB | |
| SCHEMBL26856740 | 0.90 | TSHR (0.35) | ALDH1A1KDM4ELOXL2TSHRSMN1; SMN2 | |
| SCHEMBL26814536 | 0.89 | PIK3CD (0.36) | MAP4K1TSHRSMN1; SMN2PIK3CDPIK3CB | |
| SCHEMBL26814745 | 0.89 | BPTF (0.35) | KDM4EMAP4K1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL26814715 | 0.87 | MAP4K1 (0.33) | MAP4K1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL26814500 | 0.86 | HTR1A (0.36) | MAP4K1TSHRSMN1; SMN2PIK3CDPIK3CB | |
| SCHEMBL24309393 | 0.84 | HTR1A (0.36) | ALDH1A1MAP4K1TSHRSMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | ALDH1A1 3992/4885KDM4E 4141/4885LOXL2 2934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.