Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.35 |
| ▸ | PDE1A | P54750 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 4/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26856905 | 0.90 | MKNK1 (0.37) | MKNK1IRAK4IRAK1HTR1AHTR7 | |
| SCHEMBL24309394 | 0.90 | CDK2 (0.40) | CCNA2CDK2HTR1AHTR7CSF1R | |
| SCHEMBL29566987 | 0.90 | CDK2 (0.40) | CCNA2CDK2HTR1AHTR7CSF1R | |
| SCHEMBL26814483 | 0.90 | CDK2 (0.39) | CCNA2CDK2HTR1AHTR7CSF1R | |
| SCHEMBL26806489 | 0.89 | CCNA2 (0.42) | CCNA2CDK2HTR1AHTR7MAP4K1 | |
| SCHEMBL26814726 | 0.88 | CCNA2 (0.40) | CCNA2CDK2HTR1AHTR7MAP4K1 | |
| SCHEMBL26814821 | 0.86 | CCNA2 (0.36) | IRAK1CCNA2CDK2HTR1AHTR7 | |
| SCHEMBL26814536 | 0.85 | PIK3CD (0.36) | HTR1AHTR7MAP4K1 | |
| SCHEMBL26814500 | 0.83 | HTR1A (0.36) | HTR1AHTR7MAP4K1 | |
| SCHEMBL26814517 | 0.83 | SMN1; SMN2 (0.38) | IRAK4HTR1AHTR7MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | MKNK1 2413/4885IRAK4 1601/4885IRAK1 2877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.