Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | BCHE | P06276 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26814906 | 0.92 | KMT2A (0.70) | CYP2D6KMT2AMEN1BCHEHRH3 | |
| SCHEMBL24370747 | 0.87 | KDM4E (0.65) | CYP2D6KMT2AMEN1BCHEHRH3 | |
| SCHEMBL11638745 | 0.85 | CYP2D6 (0.77) | CYP2D6KMT2AMEN1HRH3KCNH2 | |
| SCHEMBL8355590 | 0.82 | CYP2D6 (0.76) | CYP2D6KMT2AMEN1BCHEHRH3 | |
| SCHEMBL19354669 | 0.82 | CYP2D6 (0.60) | CYP2D6KMT2AMEN1HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL8622970 | 0.81 | CYP2D6 (0.74) | CYP2D6KMT2AMEN1BCHEHRH3 | |
| SCHEMBL10761732 | 0.80 | ALDH1A1 (0.58) | CYP2D6KMT2AMEN1HRH3KCNH2 | |
| SCHEMBL19321863 | 0.79 | CYP2D6 (0.67) | CYP2D6KMT2AMEN1HRH3KCNH2 | |
| SCHEMBL26820898 | 0.79 | ATM (0.71) | KMT2AMEN1BCHELMNASMN1; SMN2 | |
| SCHEMBL3326110 | 0.78 | CYP2D6 (0.70) | CYP2D6KMT2AMEN1HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | CYP2D6 805/4885KMT2A 4505/4885MEN1 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.