Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13838519 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2KMOALDH1A1LMNAMAPT | |
| SCHEMBL6278071 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KMOALDH1A1LMNAMAPT | |
| SCHEMBL5063444 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2KMOALDH1A1LMNAMAPT | |
| SCHEMBL5068065 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2KMOALDH1A1LMNAMAPT | |
| SCHEMBL420682 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2KMOALDH1A1LMNACYP2C19 | |
| SCHEMBL8103794 | 0.75 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MAPTLRRK2CYP2C19 | |
| SCHEMBL29037233 | 0.75 | MKNK1 (0.50) | SMN1; SMN2KMOALDH1A1LMNAMAPT | |
| SCHEMBL25256533 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2KMOALDH1A1MAPTCYP2C19 | |
| SCHEMBL1092164 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTCYP2C19 | |
| SCHEMBL8785006 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2KMOALDH1A1LRRK2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | NR1H2, NR1H3, NR1H4 | SMN1; SMN2 4853/4885KMO 1292/4885ALDH1A1 3993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.