Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178556 | 0.89 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP3A4SIRT1ALOX5 | |
| SCHEMBL2681962 | 0.80 | PTGS1 (0.64) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL8670047 | 0.80 | CYP1A2 (0.59) | CYP1A2CYP2C9CYP3A4ALOX5PTGS1 | |
| SCHEMBL8291651 | 0.80 | PTGS1 (0.64) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL2681961 | 0.80 | PTGS1 (0.64) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL8670044 | 0.80 | CYP1A2 (0.59) | CYP1A2CYP2C9CYP3A4ALOX5PTGS1 | |
| SCHEMBL6851613 | 0.75 | CYP1A2 (1.00) | CYP1A2CYP2C9CYP3A4SIRT1PTGS2 | |
| SCHEMBL6851627 | 0.75 | CYP1A2 (1.00) | CYP1A2CYP2C9CYP3A4SIRT1PTGS2 | |
| SCHEMBL6854900 | 0.72 | CYP1A2 (0.87) | CYP1A2CYP2C9CYP3A4KMT2AMAPT | |
| SCHEMBL6851658 | 0.72 | CYP1A2 (0.87) | CYP1A2CYP2C9CYP3A4KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8669289-B2 | Methods and compositions relating to hematologic malignancies | THE JACKSON LABORATORY (US) | 2014-03-11 | — | — | US | disclosed |
| US-8486922-B2 | Composition | CHEN CHIEN-HUNG (TW) | 2013-07-16 | — | — | US | disclosed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120114605-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOLOGIC MALIGNANCIES | THE JACKSON LABORATORY | 2012-05-10 | — | — | US | disclosed |
| WO-2010124283-A2 | METHODS AND COMPOSITIONS RELATING TO HEMATOLOGIC MALIGNANCIES | THE JACKSON LABORATORY (US) | 2010-10-28 | — | — | WO | disclosed |