SCHEMBL26832425

SCHEMBL26832425

CCN1C(=O)c2ccc(C(=O)Oc3ccc(-c4ccc(OC(=O)c5ccc6c(c5)C(=O)N(CC)C6=O)cc4)cc3)cc2C1=O

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.61
ALDH1A1 P00352 9/20 0.54
MEN1 O00255 4/20 0.51
KMT2A Q03164 4/20 0.51
LMNA P02545 1/20 0.50
FNTA P49354 1/20 0.49
FNTB P49356 1/20 0.49
TSHR P16473 2/20 0.49
GAA P10253 1/20 0.49
RAB9A P51151 2/20 0.46
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA4 P22748 1/20 0.43
CA9 Q16790 1/20 0.43
MAPK1 P28482 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26832428 0.96 POLB (0.66) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL26832421 0.94 POLB (0.64) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL10046075 0.91 POLB (0.59) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL26832445 0.86 ALDH1A1 (0.51) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL19755147 0.85 FNTA (0.52) ALDH1A1MEN1KMT2AFNTAFNTB
SCHEMBL26832433 0.84 POLB (0.52) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL26832436 0.84 POLB (0.54) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL26832432 0.83 KMT2A (0.51) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL9175052 0.83 ALDH1A1 (0.51) POLBALDH1A1MEN1KMT2ALMNA
SCHEMBL26832447 0.82 ALDH1A1 (0.47) POLBALDH1A1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11834598-B2 Dielectric copolymer materials MERCK PATENT GMBH (DE) 2023-12-05 US disclosed