Methylene Chloride

Methylene Chloride

SCHEMBL2683607

CCN(C(C)C)C(C)C.ClCCl

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylene Chloride SCHEMBL951080 0.94 MEN1 (0.46) MEN1KMT2AALDH1A1TSHR
1,2-Dichloroethane SCHEMBL25301300 0.90 MEN1 (0.55) MEN1KMT2AALDH1A1TSHR
SCHEMBL5544690 0.89 MEN1 (0.42) MEN1KMT2A
SCHEMBL7097725 0.89
SCHEMBL1746 0.89
Chlorolithium SCHEMBL27996451 0.87 MEN1 (0.43) MEN1KMT2A
Chloroform SCHEMBL6141197 0.87 MEN1 (0.43) MEN1KMT2AALDH1A1TSHR
SCHEMBL6063151 0.87 MEN1 (0.43) MEN1KMT2AALDH1A1TSHR
SCHEMBL4912357 0.87 MEN1 (0.43) MEN1KMT2A
SCHEMBL319537 0.86 MEN1 (0.40) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105732458-B Pyrrole amides class compound and preparation method thereof and purposes 成都先导药物开发有限公司 2019-06-07 CN claimed
CN-105732459-B Pyrrole amides class compound and preparation method thereof and purposes 成都先导药物开发有限公司 2019-05-31 CN claimed
CN-105732459-A Pyrrole amide compounds, preparation method and applications thereof 成都先导药物开发有限公司 2016-07-06 CN claimed
CN-105732458-A Pyrrole amide compounds, preparation method and applications thereof 成都先导药物开发有限公司 2016-07-06 CN claimed
EP-0208641-B1 MULTI-SYNTHETIZER AND SEMI-AUTOMATIC SYNTHESIS PROCESS OF PEPTIDES IN THE SOLID PHASE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1989-09-20 EP claimed
WO-2024043319-A1 ANTIBODY-DRUG COMPLEX エーザイ・アール・アンド・ディー・マネジメント株式会社 2024-02-29 WO disclosed
WO-2024002378-A1 COMPOUND HAVING KINASE INHIBITORY FUNCTION, AND PREPARATION AND APPLICATION THEREOF 上海轶诺药业有限公司 2024-01-04 WO disclosed
WO-2023210740-A1 BENZOTHIOPHENE COMPOUND 第一三共株式会社 2023-11-02 WO disclosed
CN-114805270-A Eriocalyxin A and eriocalyxin B and preparation method thereof 中国科学院昆明植物研究所 2022-07-29 CN disclosed
CN-105283454-B Quinazoline and azepine quinazoline as RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/MTOR access double inhibitor ASANA BIOSCIENCES, LLC (US) 2019-10-29 CN disclosed
CN-110167932-A Process for the preparation of (3S, 4S) -4-isopropyl-6, 7-dihydro-3H-imidazo [4, 5-c ] pyridine-5 (4H) -carboxylic acid tetrahydrofuran-3-yl ester 博善人工智能剑桥有限公司 2019-08-23 CN disclosed
CN-105431420-B Diheteroaryl compounds and uses thereof 豪夫迈·罗氏有限公司 2019-08-13 CN disclosed
EP-0759934-B1 NEUROTENSIN ANTAGONIST PEPTIDES RHONE POULENC RORER SA (FR) 1999-04-14 EP disclosed
WO-1998029390-A1 FARNESYL TRANSFERASE INHIBITORS RHONE-POULENC RORER S.A. (FR) 1998-07-09 WO disclosed
EP-0839133-A1 4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS Aventis Pharma S.A. (FR) 1998-05-06 EP disclosed
WO-1997003050-A1 4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS RHONE-POULENC RORER S.A. (FR) 1997-01-30 WO disclosed
US-5591769-A PYRROLIDINE DERIVATIVES; ANTICOAGULANTS KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
EP-0369816-A2 Monoclonal antibodies specific for human polymorphic epithelial mucin THE UNIVERSITY OF MELBOURNE (AU) 1990-05-23 EP disclosed
US-4395404-A PEPTIDES WITH A GLYCINE-GLUTAMIC ACID-SERINE BASE GEORGE WASHINGTON UNIVERSITY (US) 1983-07-26 US disclosed
US-4145337-A SOMATOSTATINS, ANTISECRETORY HOFFMANN-LA ROCHE INC. (US) 1979-03-20 US disclosed