Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 13/20 | 0.67 |
| ▸ | SPPL2B | Q8TCT7 | 1/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26848272 | 0.97 | SPPL2A (0.66) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848295 | 0.81 | SPPL2A (0.60) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848223 | 0.80 | SPPL2A (1.00) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL31654095 | 0.77 | SPPL2A (1.00) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL31458868 | 0.77 | SPPL2A (1.00) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26854539 | 0.70 | SPPL2A (1.00) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30617042 | 0.69 | SPPL2A (0.59) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848298 | 0.69 | SPPL2A (0.59) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL25409439 | 0.68 | SPPL2A (0.51) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26854629 | 0.67 | SPPL2A (0.76) | SPPL2ASPPL2BPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214210-B1 | COMPOUNDS AND COMPOSITIONS AS SPPL2A INHIBITORS | NOVARTIS AG (CH) | 2025-04-09 | — | — | EP | claimed |
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | claimed |
| EP-4578451-A2 | COMPOUNDS AND COMPOSITIONS AS SPPL2A INHIBITORS | Novartis AG (CH) | 2025-07-02 | — | — | EP | disclosed |
| EP-4214210-B1 | COMPOUNDS AND COMPOSITIONS AS SPPL2A INHIBITORS | NOVARTIS AG (CH) | 2025-04-09 | — | — | EP | disclosed |
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | SPPL2A, SPPL2B, BACE1 | SPPL2A 1/4885SPPL2B 2/4885PSEN1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.