Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 10/20 | 1.00 |
| ▸ | SPPL2B | Q8TCT7 | 1/20 | 1.00 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31458868 | 1.00 | SPPL2A (1.00) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848272 | 0.79 | SPPL2A (0.66) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848251 | 0.77 | SPPL2A (0.67) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848295 | 0.75 | SPPL2A (0.60) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL30617042 | 0.74 | SPPL2A (0.59) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848298 | 0.74 | SPPL2A (0.59) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL25409439 | 0.70 | SPPL2A (0.51) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26848196 | 0.65 | SPPL2A (0.48) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL26847776 | 0.65 | SPPL2A (0.46) | SPPL2ASPPL2BPSEN1PSEN2APH1B | |
| SCHEMBL25405855 | 0.64 | SPPL2A (0.47) | SPPL2ASPPL2BPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250213585-A1 | COMPOSITIONS AND METHODS OF A CONCOMITANT THERAPY OF ALTERNATING ELECTRIC FIELDS AND NOTCH-1 INHIBITOR | SHANGHAI INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY (CN) | 2025-07-03 | — | — | US | claimed |
| US-20250213585-A1 | COMPOSITIONS AND METHODS OF A CONCOMITANT THERAPY OF ALTERNATING ELECTRIC FIELDS AND NOTCH-1 INHIBITOR | SHANGHAI INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY (CN) | 2025-07-03 | — | — | US | disclosed |