Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K3 | P46734 | 3/20 | 0.56 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668419 | 0.83 | MAP2K3 (0.53) | MAP2K3NNMTSMN1; SMN2PDPK1MEN1 | |
| SCHEMBL16505772 | 0.78 | MAP2K3 (0.53) | MAP2K3PDPK1MEN1KMT2AIKBKB | |
| SCHEMBL15275826 | 0.78 | GRM5 (0.54) | MAP2K3PDPK1MEN1KMT2AIKBKB | |
| SCHEMBL6833172 | 0.78 | MAP2K3 (0.53) | MAP2K3PDPK1MEN1KMT2AIKBKB | |
| SCHEMBL16505248 | 0.78 | MAP2K3 (0.53) | MAP2K3PDPK1MEN1KMT2AIKBKB | |
| SCHEMBL2159117 | 0.74 | MAP2K3 (0.49) | MAP2K3PDPK1KMT2AIKBKBALDH1A1 | |
| SCHEMBL11708941 | 0.74 | MAPT (0.48) | MAP2K3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL14358203 | 0.74 | NNMT (0.54) | MAP2K3NNMTIKBKBMKNK1MKNK2 | |
| SCHEMBL31378785 | 0.72 | MAP2K3 (0.51) | MAP2K3 | |
| SCHEMBL27896613 | 0.72 | MAP2K3 (0.51) | MAP2K3MEN1KMT2AIKBKBMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |