Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770906 | 0.90 | AGTR1 (0.51) | EDNRAAGTR1AGTR2PPARG | |
| SCHEMBL4773767 | 0.90 | AGTR1 (0.52) | EDNRAAGTR1AGTR2EDNRB | |
| SCHEMBL4764544 | 0.86 | AGTR1 (0.52) | EDNRAAGTR1AGTR2PPARG | |
| SCHEMBL4769578 | 0.86 | AGTR1 (0.48) | EDNRAAGTR1AGTR2EDNRBPPARG | |
| SCHEMBL4770187 | 0.86 | EDNRA (0.57) | EDNRAAGTR1AGTR2EDNRB | |
| SCHEMBL4773295 | 0.85 | AGTR1 (0.48) | EDNRAAGTR1AGTR2EDNRBPPARG | |
| SCHEMBL4773168 | 0.85 | AGTR1 (0.47) | EDNRAAGTR1AGTR2EDNRBPPARG | |
| SCHEMBL4764391 | 0.84 | AGTR1 (0.49) | EDNRAAGTR1AGTR2EDNRBPPARG | |
| SCHEMBL4766250 | 0.84 | EDNRA (0.60) | EDNRAAGTR1AGTR2EDNRBPPARG | |
| SCHEMBL4764367 | 0.84 | AGTR1 (0.48) | EDNRAAGTR1AGTR2EDNRBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |