Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.37 |
| ▸ | CDK2 | P24941 | 9/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26869018 | 0.97 | CHEK1 (0.37) | CHEK1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL26868021 | 0.94 | CHEK1 (0.36) | CHEK1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL26868955 | 0.84 | CHEK1 (0.54) | CHEK1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL26871180 | 0.84 | KCNH2 (0.36) | KDM4ENPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL26868957 | 0.83 | CDK2 (0.38) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL26869017 | 0.83 | CHEK1 (0.37) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL26869020 | 0.82 | CDK2 (0.54) | CHEK1CCNA2CDK2CCNA1HTR6 | |
| SCHEMBL26869088 | 0.81 | CDK2 (0.38) | CHEK1CCNA2CDK2CCNA1HTR6 | |
| SCHEMBL26868953 | 0.81 | CHEK1 (0.33) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14492455 | 0.80 | KCNH2 (0.38) | KDM4EMAPTRAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4282868-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVE, AND COMPOSITIONS AND MEDICAL USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd (CN) | 2023-11-29 | — | — | EP | disclosed |