Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 6/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26670528 | 0.90 | PARP10 (0.46) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL26696046 | 0.88 | PDE4A (0.49) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL30714655 | 0.85 | PARP10 (0.43) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL30714586 | 0.85 | PARP10 (0.43) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL26868980 | 0.84 | PARP10 (0.41) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL30714595 | 0.84 | GPR132 (0.43) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL26868378 | 0.83 | GRM5 (0.42) | PARP10MAPK14SMOCYP2C9MAPK1 | |
| SCHEMBL30714591 | 0.83 | PARP10 (0.41) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL30714696 | 0.83 | SMO (0.42) | PARP10MAPK14SMOPDE5APDE4A | |
| SCHEMBL26869339 | 0.83 | SMO (0.42) | PARP10MAPK14SMOPDE5APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023230540-A2 | INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |