Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL268704 | 0.92 | SCN9A (0.43) | SCN9ASCN10ACYP3A4ANO1AAK1 | |
| SCHEMBL268823 | 0.92 | KLK5 (0.36) | SCN9ASCN10ACYP3A4ANO1SGMS2 | |
| SCHEMBL269942 | 0.89 | SCN9A (0.39) | SCN9ASCN10ACYP3A4ANO1AAK1 | |
| SCHEMBL269081 | 0.88 | ANO1 (0.41) | SCN9ASCN10AANO1KLK5CTSS | |
| SCHEMBL269043 | 0.87 | S1PR3 (0.37) | SCN9ASCN10ACYP3A4ANO1KLK5 | |
| SCHEMBL268318 | 0.85 | CTSS (0.44) | SCN9ASCN10ACYP3A4ANO1KLK5 | |
| SCHEMBL268317 | 0.85 | CTSS (0.44) | SCN9ASCN10ACYP3A4ANO1KLK5 | |
| SCHEMBL267895 | 0.85 | ANO1 (0.46) | SCN9ASCN10ACYP3A4ANO1SGMS2 | |
| SCHEMBL270332 | 0.85 | SCN9A (0.49) | SCN9ASCN10ACYP3A4ANO1SGMS2 | |
| Hydrochloric Acid SCHEMBL4094841 | 0.85 | ANO1 (0.45) | SCN9ASCN10ACYP3A4ANO1SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133907-B2 | Type II diabetes, obesity, hyperglycemia and a lipid disorder selected from dyslipidemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL and high LDL; additionally comprising metformin | ELI LILLY AND COMPANY (US) | 2012-03-13 | — | — | US | disclosed |
| EP-1912946-B1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | LILLY CO ELI (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080214616-A1 | Pyridine Derivatives as Dipeptedyl Peptidase Inhibitors | ELI LILLY AND COMPANY | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214616-A1 | Pyridine Derivatives as Dipeptedyl Peptidase Inhibitors | DPP4, DPP3, DPP7 | SCN9A 1412/4885SCN10A 461/4885CYP3A4 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.