Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316372 | 1.00 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL26880996 | 1.00 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL26662512 | 0.90 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL26662516 | 0.90 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL31316444 | 0.90 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL30742393 | 0.89 | PIK3CA (0.40) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL26881116 | 0.89 | PIK3CA (0.40) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL26881137 | 0.84 | POLB (0.36) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL30584377 | 0.84 | POLB (0.36) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 | |
| SCHEMBL30322546 | 0.83 | PIK3CA (0.40) | ALDH1A1L3MBTL1POLBATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769546-A | Allosteric ketene inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease | 佩特拉制药公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2023212693-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PETRA PHARMA CORPORATION (US) | 2023-11-02 | — | — | WO | disclosed |