Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.77 |
| ▸ | MAP3K20 | Q9NYL2 | 8/20 | 0.77 |
| ▸ | CSK | P41240 | 6/20 | 0.77 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.77 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.77 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.77 |
| ▸ | ABL1 | P00519 | 3/20 | 0.77 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.77 |
| ▸ | RAF1 | P04049 | 2/20 | 0.77 |
| ▸ | LYN | P07948 | 2/20 | 0.77 |
| ▸ | SRC | P12931 | 2/20 | 0.77 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.77 |
| ▸ | ABL2 | P42684 | 2/20 | 0.77 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.77 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29725987 | 0.87 | MAPK14 (1.00) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL2284518 | 0.87 | MAPK14 (1.00) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL2284510 | 0.87 | MAPK14 (1.00) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL16786132 | 0.84 | MAPK14 (0.95) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL26882862 | 0.83 | DDR1 (0.78) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL16581650 | 0.78 | CSK (0.60) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL16581606 | 0.78 | CSK (0.60) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL29496497 | 0.77 | MAPK14 (0.83) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL2284669 | 0.77 | MAPK14 (0.83) | MAPK14MAP3K20CSKMAP3K7MAP4K2 | |
| SCHEMBL2284678 | 0.77 | MAPK14 (0.83) | MAPK14MAP3K20CSKMAP3K7MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11826365-B2 | Type II raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11826365-B2 | Type II raf kinase inhibitors | BRAF, RAF1, ARAF | MAPK14 182/4885MAP3K20 6/4885CSK 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.