Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSK | P41240 | 5/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.58 |
| ▸ | ABL2 | P42684 | 1/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.58 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16581650 | 1.00 | CSK (0.60) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL16581619 | 0.88 | SRC (0.49) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL16581602 | 0.88 | SRC (0.49) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL16581559 | 0.79 | MAPK14 (0.76) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL16581560 | 0.79 | MAPK14 (0.76) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL2286190 | 0.78 | CSK (0.60) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL2286181 | 0.78 | CSK (0.60) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL26882912 | 0.78 | MAPK14 (0.77) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL12518518 | 0.75 | CSK (0.57) | CSKMAP3K20MAPK14SRCMAP3K7 | |
| SCHEMBL16581617 | 0.74 | CSK (0.63) | CSKMAP3K20MAPK14SRCMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2015-03-25 | — | — | EP | claimed |