SCHEMBL2688348

SCHEMBL2688348

C=C1[C@H](O[Si](C)(C)C(C)(C)C)CC(=CC(=O)OC)C[C@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10041393 0.92
SCHEMBL9070725 0.86
SCHEMBL4331530 0.86
SCHEMBL1604156 0.85
SCHEMBL14107873 0.80
SCHEMBL9010728 0.80
SCHEMBL8339699 0.77
SCHEMBL14523029 0.77
SCHEMBL629011 0.77
SCHEMBL14107815 0.76 STAT3 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180327354-A1 Unnatural Analogues of Calcitriol and Uses Thereof VIDASYM, LLC 2018-11-15 US disclosed
EP-2419403-B1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF VIDASYM INC (US) 2016-09-07 EP disclosed
US-8575136-B2 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2013-11-05 US disclosed
EP-1268415-B1 26,27-HOMOLOGATED-20-EPI-2-ALKYL-19-NOR-VITAMIN D COMPOUNDS WISCONSIN ALUMNI RES FOUND (US) 2013-05-29 EP disclosed
US-8404666-B2 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2013-03-26 US disclosed
US-8222235-B2 2-methylene-19-nor-(20R)-1α-hydroxy-bishomopregnacalciferol WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-07-17 US disclosed
US-8188064-B2 Reducing cell differentiation of adipocyte; reducing body fat WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-05-29 US disclosed
US-20120115824-A1 Vitamin D Receptor Agonists and Uses Thereof VIDASYM, LLC (US) 2012-05-10 US disclosed
US-20120115824-A1 Vitamin D Receptor Agonists and Uses Thereof VIDASYM, LLC (US) 2012-05-10 US disclosed
US-7915242-B2 eczema, hypercalcemia, hyperparathyroidism, sarcoidosis, or vitamin D intoxication WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2011-03-29 US disclosed
EP-0970047-B1 2-ALKYLIDENE-19-NOR-VITAMIN D COMPOUNDS WISCONSIN ALUMNI RES FOUND (US) 2002-09-11 EP disclosed
US-20020123638-A1 26,27-homologated-20-epi-2-alkyl-19-nor-vitamin D compounds WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2002-09-05 US disclosed
US-20020087015-A1 26,27-homologated-20-EPI-2-alklidene-19-nor-vitamin D compounds WISCONSIN ALUMNI RESEARCH FOUNDATION OF MADISON 2002-07-04 US disclosed
US-6392071-B1 ANTICANCER AGENTS WISCONSIN ALUMNI: RESEARCH FOUNDATION 2002-05-21 US disclosed
US-6316642-B1 FOR THERAPY OF OSTEOPOROSIS AND PSORIASIS, AS ANTICANCER AGENT WISCONSIN ALUMNI RESEARCH FOUNDATION 2001-11-13 US disclosed
WO-2001074766-A1 2-ALKYLIDENE-19-NOR-VITAMIN D COMPOUNDS AND THEIR THERAPEUTIC USES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2001-10-11 WO disclosed
WO-2001074765-A1 26,27-HOMOLOGATED-20-EPI-2-ALKYL-19-NOR-VITAMIN D COMPOUNDS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2001-10-11 WO disclosed
US-6277837-B1 TREATMENT OF PSORIASIS, LEUKEMIA, CANCERS, OSTEOPOROSIS WISCONSIN ALUMNI RESEARCH FOUNDATION 2001-08-21 US disclosed
EP-0971888-A1 2-ALKYL-19-NOR-VITAMIN D COMPOUNDS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2000-01-19 EP disclosed
WO-1998041500-A1 2-ALKYL-19-NOR-VITAMIN D COMPOUNDS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1998-09-24 WO disclosed