Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.47 |
| ▸ | PLK1 | P53350 | 15/20 | 0.42 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.42 |
| ▸ | PRKDC | P78527 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2689719 | 1.00 | BRD4 (0.47) | BRD4PLK1PLK2PRKDC | |
| SCHEMBL5928523 | 1.00 | BRD4 (0.47) | BRD4PLK1PLK2PRKDC | |
| SCHEMBL2689723 | 1.00 | BRD4 (0.47) | BRD4PLK1PLK2PRKDC | |
| SCHEMBL1288295 | 0.94 | BRD4 (0.51) | BRD4PLK1PLK2PRKDC | |
| SCHEMBL1288293 | 0.94 | BRD4 (0.51) | BRD4PLK1PLK2PRKDC | |
| SCHEMBL1288651 | 0.88 | BRD4 (0.55) | BRD4PLK1PLK2 | |
| SCHEMBL1288648 | 0.88 | BRD4 (0.55) | BRD4PLK1PLK2 | |
| SCHEMBL1288485 | 0.86 | BRD4 (0.58) | BRD4PLK1PLK2 | |
| SCHEMBL1288479 | 0.86 | BRD4 (0.58) | BRD4PLK1PLK2 | |
| SCHEMBL383800 | 0.86 | BRD4 (0.60) | BRD4PLK1PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | PLK1, POLR2E, POLR2H | BRD4 1149/4885PLK1 1/4885PLK2 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.