Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4175458 | 0.83 | HPGD (0.49) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL4341580 | 0.82 | HPGD (0.59) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL20857323 | 0.80 | HPGD (0.56) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL22827996 | 0.78 | HPGD (0.45) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL3224829 | 0.78 | CNR1 (0.41) | EPHX2CNR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26168283 | 0.76 | CNR1 (0.43) | CNR1ALDH1A1 | |
| SCHEMBL24158323 | 0.75 | HPGD (0.47) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL18771741 | 0.75 | HPGD (0.44) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL14943389 | 0.74 | HPGD (0.50) | HPGDNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL19146110 | 0.73 | SDCBP (0.35) | EPHX2CNR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059472-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2023225661-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-11-23 | — | — | WO | disclosed |