Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26675311 | 0.88 | MAPT (0.42) | MAPTTP53HTTHCRTR2ALDH1A1 | |
| SCHEMBL30600513 | 0.88 | MAPT (0.42) | MAPTTP53HTTHCRTR2ALDH1A1 | |
| SCHEMBL29767947 | 0.78 | HTT (0.42) | MAPTTP53HTTHCRTR2POLB | |
| SCHEMBL30600506 | 0.78 | MAPT (0.49) | MAPTTP53HTTALDH1A1POLB | |
| SCHEMBL26675364 | 0.78 | HTT (0.42) | MAPTTP53HTTHCRTR2POLB | |
| SCHEMBL26675313 | 0.78 | MAPT (0.49) | MAPTTP53HTTALDH1A1POLB | |
| SCHEMBL30600526 | 0.76 | HCRTR1 (0.38) | MAPTTP53HTTHCRTR2POLB | |
| SCHEMBL26675328 | 0.76 | HCRTR1 (0.38) | MAPTTP53HTTHCRTR2POLB | |
| SCHEMBL30600516 | 0.76 | MAPT (0.39) | MAPTTP53HTTHCRTR2ALDH1A1 | |
| SCHEMBL26675334 | 0.76 | MAPT (0.39) | MAPTTP53HTTHCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4284797-A1 | PYRAZOLEAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022162034-A1 | PYRAZOLEAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-08-04 | — | — | WO | disclosed |