Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26675334 | 1.00 | MAPT (0.39) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL26908764 | 0.95 | MAPT (0.43) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL26675304 | 0.88 | P2RX7 (0.36) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL30600528 | 0.88 | P2RX7 (0.36) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL26675311 | 0.88 | MAPT (0.42) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL30600513 | 0.88 | MAPT (0.42) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL26908761 | 0.87 | HCRTR2 (0.33) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL30600506 | 0.86 | MAPT (0.49) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL29767947 | 0.86 | HTT (0.42) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL26675313 | 0.86 | MAPT (0.49) | MAPTHTTSMN1; SMN2TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867782-A | Pyrazole amide derivative | 豪夫迈·罗氏有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-116867782-A | Pyrazole amide derivative | 豪夫迈·罗氏有限公司 | 2023-10-10 | — | — | CN | disclosed |