Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLEC | Q15149 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482151 | 0.69 | DAO (1.00) | DAOKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1673185 | 0.69 | DAO (0.61) | DAOKDM4ETP53TSHRALDH1A1 | |
| SCHEMBL9300916 | 0.66 | DAO (0.57) | DAOKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1618278 | 0.66 | KDM4E (0.59) | KDM4ETP53TSHRERCC5FEN1 | |
| SCHEMBL19577293 | 0.63 | KDM4E (0.61) | DAOKDM4ETP53TSHRGLS | |
| SCHEMBL6021687 | 0.63 | DAO (0.44) | DAOKDM4ETSHRALDH1A1 | |
| SCHEMBL4867761 | 0.63 | MAPK1 (0.48) | KDM4ETP53TSHRERCC5FEN1 | |
| SCHEMBL873035 | 0.62 | DAO (0.76) | DAOKDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL31609342 | 0.62 | DAO (0.76) | DAOKDM4EALDH1A1SMN1; SMN2POLB | |
| Formamide SCHEMBL5394856 | 0.62 | DAO (0.81) | DAOKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168605-B2 | Polymeric oligonucleotide prodrugs | ENZON PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090318538-A1 | POLYMERIC OLIGONUCLEOTIDE PRODRUGS | ENZON PHARMACEUTICALS, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-7595304-B2 | Polymeric oligonucleotide prodrugs | ENZON PHARMACEUTICALS, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| EP-1503760-A4 | CAMPTOTHECIN DERIVATIVES AND POLYMERIC CONJUGATES THEREOF | ENZON INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1503760-A1 | CAMPTOTHECIN DERIVATIVES AND POLYMERIC CONJUGATES THEREOF | ENZON, INC. (US) | 2005-02-09 | — | — | EP | disclosed |
| US-20040235773-A1 | Polymeric oligonucleotide prodrugs | BELROSE PHARMA INC. | 2004-11-25 | — | — | US | disclosed |
| WO-2003097356-A9 | CAMPTOTHECIN DERIVATIVES AND POLYMERIC CONJUGATES THEREOF | ENZON INC (US) | 2004-11-11 | — | — | WO | disclosed |
| WO-2003097356-A1 | CAMPTOTHECIN DERIVATIVES AND POLYMERIC CONJUGATES THEREOF | ENZON, INC (US) | 2003-11-27 | — | — | WO | disclosed |
| US-6608076-B1 | Treating topoisomerase I inhibitor-related disease in mammals | ENZON, INC. | 2003-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318538-A1 | POLYMERIC OLIGONUCLEOTIDE PRODRUGS | TYMP, PAICS, DPYD | DAO 1098/4885KDM4E 4230/4885TP53 132/4885 |
| US-20040235773-A1 | Polymeric oligonucleotide prodrugs | TYMP, PAICS, DPYD | DAO 1098/4885KDM4E 4230/4885TP53 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.