Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.81 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482151 | 0.90 | DAO (1.00) | DAOAKR1C3KDM4EMAOAMAOB | |
| SCHEMBL31609342 | 0.78 | DAO (0.76) | DAOKDM4EMAOAMAOBFTO | |
| SCHEMBL873035 | 0.78 | DAO (0.76) | DAOKDM4EMAOAMAOBFTO | |
| SCHEMBL1771484 | 0.74 | DAO (0.70) | DAOAKR1C3KDM4EMAOAMAOB | |
| SCHEMBL1673185 | 0.69 | DAO (0.61) | DAOKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL31538134 | 0.67 | DAO (0.53) | DAOAKR1C3KDM4EALDH1A1MAPT | |
| SCHEMBL9411282 | 0.67 | DAO (0.61) | DAOAKR1C3KDM4EALDH1A1GLA | |
| SCHEMBL15797268 | 0.66 | DAO (0.56) | DAOAKR1C3KDM4EMAOAMAOB | |
| SCHEMBL9300916 | 0.65 | DAO (0.57) | DAOKDM4EALDH1A1HSD17B10 | |
| SCHEMBL30619613 | 0.64 | DAO (0.56) | DAOKDM4EMAOAMAOBFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217727-B2 | Phospholipase inhibitors | ELI LILLY AND COMPANY (US) | 2007-05-15 | — | — | US | disclosed |
| US-20060116409-A1 | Phospholipase inhibitors | ELILILLY AND COMPANY | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116409-A1 | Phospholipase inhibitors | LIPG, PNLIP, LIPC | DAO 1566/4885AKR1C3 3066/4885KDM4E 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.