Sugi Predict

Sugi Predict / Compounds / SCHEMBL26918079

SCHEMBL26918079

SCHEMBL26918079

CC(C)c1cc(-n2ccnn2)ccc1N

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 13/20 0.57
▸ KEAP1 Q14145 1/20 0.44
▸ CYP19A1 P11511 1/20 0.40
▸ USP1 O94782 3/20 0.37
▸ WDR48 Q8TAF3 3/20 0.37
▸ USP7 Q93009 1/20 0.37
▸ KDM5B Q9UGL1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7404546 0.80 NOTUM (0.58) NOTUMKEAP1CYP19A1
SCHEMBL20437909 0.79 NOTUM (0.58) NOTUMKEAP1CYP19A1USP1WDR48
SCHEMBL24925228 0.78 NOTUM (0.57) NOTUMKEAP1CYP19A1USP1WDR48
SCHEMBL20444416 0.78 NOTUM (0.57) NOTUMKEAP1CYP19A1USP1WDR48
SCHEMBL2359098 0.77 NOTUM (0.54) NOTUMKEAP1CYP19A1
SCHEMBL22325390 0.76 NOTUM (0.53) NOTUMKEAP1CYP19A1
SCHEMBL13122736 0.75 NOTUM (0.63) NOTUMKEAP1CYP19A1
SCHEMBL27818248 0.73 NOTUM (0.50) NOTUMKEAP1CYP19A1
SCHEMBL12794021 0.73 NOTUM (1.00) NOTUMKEAP1CYP19A1USP1KDM5B
SCHEMBL15362397 0.71 NOTUM (0.65) NOTUMKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4288429-A1 LACTAMS AS CBL-B INHIBITORS Genentech, Inc. (US) 2023-12-13 — — EP disclosed
EP-4288428-A1 AMIDES AS CBL-B INHIBITORS Genentech, Inc. (US) 2023-12-13 — — EP disclosed
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