⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23208898 | 0.88 | ACACB (0.35) | — | |
| SCHEMBL24740796 | 0.86 | JAK2 (0.33) | — | |
| SCHEMBL26920838 | 0.86 | LPL (0.31) | — | |
| SCHEMBL21631597 | 0.81 | PTPN11 (0.34) | — | |
| SCHEMBL26921302 | 0.80 | — | — | |
| SCHEMBL21653819 | 0.78 | FFAR1 (0.32) | — | |
| SCHEMBL21631662 | 0.78 | PTPN11 (0.35) | — | |
| SCHEMBL29993835 | 0.78 | — | — | |
| SCHEMBL26921676 | 0.76 | PTPN11 (0.33) | — | |
| SCHEMBL23209055 | 0.74 | PTPN11 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109900-A1 | AZABICYCLIC SHP2 INHIBITORS | PROMIDIS S.R.L. (IT) | 2024-04-04 | — | — | US | disclosed |
| EP-4288431-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2023-12-13 | — | — | EP | disclosed |
| CN-116323622-A | Bicyclic heteroaryl derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2022237178-A1 | BICYCLIC HETEROARYL DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2022-11-17 | — | — | WO | disclosed |
| WO-2022167682-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-08-11 | — | — | WO | disclosed |