SCHEMBL26922682

SCHEMBL26922682

FC(F)Oc1ccc2c(c1)NCC2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GFER P55789 2/20 0.40
HRH3 Q9Y5N1 2/20 0.39
PPARG P37231 3/20 0.38
PPARD Q03181 3/20 0.38
PPARA Q07869 3/20 0.38
CHRNB2 P17787 1/20 0.38
CHRNA7 P36544 1/20 0.38
CHRNA4 P43681 1/20 0.38
ALOX15 P16050 1/20 0.38
ADAM17 P78536 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
DRD2 P14416 1/20 0.37
DRD4 P21917 1/20 0.37
CPS1 P31327 1/20 0.36
POLB P06746 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
DRD1 P21728 1/20 0.35
APP P05067 1/20 0.35
MAP2K1 Q02750 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17785785 0.90 HRH3 (0.49) GFERHRH3PPARGPPARDPPARA
SCHEMBL15897874 0.83 GFER (0.47) GFERHRH3PPARGPPARDPPARA
SCHEMBL21635492 0.80 EIF2AK2 (0.47) GFERHRH3PPARGPPARDPPARA
SCHEMBL7983177 0.79 CES1 (0.41) GFERHRH3SMN1; SMN2DRD2DRD4
SCHEMBL29775174 0.79 CES1 (0.41) GFERHRH3SMN1; SMN2DRD2DRD4
SCHEMBL19675394 0.79 SMN1; SMN2 (0.43) GFERHRH3PPARGPPARDPPARA
SCHEMBL21753264 0.77 ADRA2A (0.51) HRH3CHRNB2CHRNA7CHRNA4DRD2
SCHEMBL30634158 0.77 MAPT (0.50) HRH3PPARGPPARDPPARACHRNB2
SCHEMBL10913730 0.77 MAPT (0.50) HRH3PPARGPPARDPPARACHRNB2
SCHEMBL30025932 0.77 HTR2C (0.50) GFERHRH3CHRNA7SMN1; SMN2DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4536363-A1 SULFAMIDE DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS Nikang Therapeutics, Inc. (US) 2025-04-16 EP disclosed
CN-119790053-A Sulfonamide derivatives as cyclin dependent kinase 2 inhibitors 霖康疗法公司 2025-04-08 CN disclosed
WO-2023240024-A1 SULFAMIDE DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS NIKANG THERAPEUTICS, INC. (US) 2023-12-14 WO disclosed