Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 15/20 | 0.70 |
| ▸ | FLT1 | P17948 | 13/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.70 |
| ▸ | FGFR3 | P22607 | 12/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.70 |
| ▸ | MELK | Q14680 | 1/20 | 0.60 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.57 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26928496 | 0.91 | KDR (0.84) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL26928536 | 0.82 | KDR (0.61) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL29418239 | 0.75 | KDR (0.85) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL30341852 | 0.75 | MELK (1.00) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL29374889 | 0.75 | MAP2K5 (0.83) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL30197767 | 0.75 | MAP2K5 (0.83) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL26928576 | 0.74 | KDR (0.69) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL31046829 | 0.73 | MAP2K5 (1.00) | KDRPDGFRBFLT1FGFR1FGFR3 | |
| SCHEMBL6598473 | 0.69 | KMT2A (0.51) | — | |
| SCHEMBL30197784 | 0.68 | PDGFRB (1.00) | KDRPDGFRBFLT1FGFR1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023240271-A1 | USE OF VEGFR2 AND FGFR1 INHIBITORS IN THERAPY | FOUNTAIN THERAPEUTICS INC. (US) | 2023-12-14 | — | — | WO | disclosed |