Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30332245 | 1.00 | LRRK2 (0.33) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL27010940 | 0.81 | LRRK2 (0.34) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL2691540 | 0.79 | AURKB (0.41) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL29004707 | 0.79 | DAO (0.39) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL30332414 | 0.79 | AURKB (0.41) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL30332332 | 0.79 | DAO (0.39) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL26661511 | 0.77 | LRRK2 (0.32) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL30406195 | 0.77 | LRRK2 (0.33) | LRRK2PDPK1 | |
| SCHEMBL2675683 | 0.77 | LRRK2 (0.33) | LRRK2PDPK1 | |
| SCHEMBL2695036 | 0.74 | FYN (0.38) | LRRK2FYNKDRCLK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023238930-A1 | ANALOGUES OF AZABICYCLIC COMPOUNDS | 大鵬薬品工業株式会社 | 2023-12-14 | — | — | WO | disclosed |
| CN-115960100-B | Synthesis method of Pi Mite xib drug for treating gastrointestinal stromal tumor | 北京康立生医药技术开发有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-115960100-A | Synthetic method of drug Pi Mite Xibu for treating gastrointestinal stromal tumor | 北京康立生医药技术开发有限公司 | 2023-04-14 | — | — | CN | disclosed |
| US-9273045-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-03-01 | — | — | US | disclosed |
| EP-2452940-B1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2014-12-17 | — | — | EP | disclosed |
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-10-09 | — | — | US | disclosed |
| US-8779142-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| EP-2452940-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2012-05-16 | — | — | EP | disclosed |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | LRRK2 3319/4885AURKA 1942/4885DAPK3 368/4885 |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | LRRK2 3319/4885AURKA 1942/4885DAPK3 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.