Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30332332 | 1.00 | DAO (0.39) | DAOPRKCILRRK2AURKADAPK3 | |
| SCHEMBL27010940 | 0.81 | LRRK2 (0.34) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL2691540 | 0.79 | AURKB (0.41) | DAOPRKCILRRK2AURKADAPK3 | |
| SCHEMBL30332245 | 0.79 | LRRK2 (0.33) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL30332414 | 0.79 | AURKB (0.41) | DAOPRKCILRRK2AURKADAPK3 | |
| SCHEMBL2693015 | 0.79 | LRRK2 (0.33) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL26661511 | 0.77 | LRRK2 (0.32) | LRRK2AURKADAPK3JAK2MAP4K4 | |
| SCHEMBL29767999 | 0.77 | PRKCI (0.40) | DAOPRKCILRRK2 | |
| SCHEMBL29079633 | 0.77 | PRKCI (0.40) | DAOPRKCILRRK2 | |
| SCHEMBL25245801 | 0.76 | PRKCI (0.42) | DAOPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115960100-B | Synthesis method of Pi Mite xib drug for treating gastrointestinal stromal tumor | 北京康立生医药技术开发有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-115960100-A | Synthetic method of drug Pi Mite Xibu for treating gastrointestinal stromal tumor | 北京康立生医药技术开发有限公司 | 2023-04-14 | — | — | CN | disclosed |