SCHEMBL26942271

SCHEMBL26942271

Cc1ccc2c(c1)CN(C(=O)N1CCNCC1)CCS2

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RYR2 Q92736 19/20 0.73
KCNH2 Q12809 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26942239 0.90 RYR2 (0.63) RYR2KCNH2
SCHEMBL26344324 0.87 RYR2 (0.58) RYR2KCNH2
SCHEMBL6867303 0.87 RYR2 (0.72) RYR2KCNH2
SCHEMBL6866744 0.85 RYR2 (0.54) RYR2
SCHEMBL6866991 0.84 RYR2 (1.00) RYR2KCNH2
SCHEMBL24460327 0.82 RYR2 (0.65) RYR2KCNH2
SCHEMBL29563318 0.82 RYR2 (0.65) RYR2KCNH2
SCHEMBL6867081 0.82 RYR2 (0.75) RYR2KCNH2
SCHEMBL26344276 0.81 RYR2 (0.53) RYR2
Hydrochloric Acid SCHEMBL29563284 0.81 RYR2 (0.64) RYR2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230399324-A1 AGENTS FOR TREATING DISORDERS INVOLVING RYANODINE RECEPTORS RYCARMA THERAPEUTICS, INC. 2023-12-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230399324-A1 AGENTS FOR TREATING DISORDERS INVOLVING RYANODINE RECEPTORS RYR2, RYR1, ATP2A1 RYR2 1/4885KCNH2 605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.