Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | GRK5 | P34947 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31734967 | 1.00 | LRRK2 (0.46) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL31734980 | 0.89 | LRRK2 (0.49) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL26953090 | 0.89 | LRRK2 (0.49) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL26953274 | 0.87 | LRRK2 (0.44) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL31734964 | 0.87 | LRRK2 (0.44) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL4790877 | 0.83 | LRRK2 (0.61) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL26953300 | 0.83 | LRRK2 (0.53) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL31734905 | 0.83 | LRRK2 (0.53) | LRRK2CDK9CDK5DYRK1BGSK3B | |
| SCHEMBL31735024 | 0.83 | LRRK2 (0.44) | LRRK2CDK5DYRK1BGSK3BCDK2 | |
| SCHEMBL26953091 | 0.83 | LRRK2 (0.44) | LRRK2CDK5DYRK1BGSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239727-A1 | LATS INHIBITORS AND USES THEREOF | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-14 | — | — | WO | disclosed |