Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | STK3 | Q13188 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31734964 | 1.00 | LRRK2 (0.44) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL31734905 | 0.89 | LRRK2 (0.53) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL26953300 | 0.89 | LRRK2 (0.53) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL31734967 | 0.87 | LRRK2 (0.46) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL26953174 | 0.87 | LRRK2 (0.46) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL26953172 | 0.86 | LRRK2 (0.41) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL31735010 | 0.82 | LRRK2 (0.50) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL26953438 | 0.82 | LRRK2 (0.50) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL26953080 | 0.82 | JAK3 (0.43) | LRRK2CDK2CDK9CDK5DYRK1B | |
| SCHEMBL26953498 | 0.79 | NUDT1 (0.58) | LRRK2CDK9CDK5DYRK1BDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239727-A1 | LATS INHIBITORS AND USES THEREOF | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-14 | — | — | WO | disclosed |