Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.64 |
| ▸ | JAK3 | P52333 | 15/20 | 0.64 |
| ▸ | JAK2 | O60674 | 13/20 | 0.63 |
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27125875 | 1.00 | JAK1 (0.64) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962782 | 0.88 | JAK1 (0.65) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL27131196 | 0.88 | JAK1 (0.65) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29892600 | 0.85 | JAK1 (0.61) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962813 | 0.85 | JAK1 (0.61) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL27133804 | 0.84 | JAK1 (0.59) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962903 | 0.84 | JAK1 (0.59) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29892586 | 0.83 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962966 | 0.83 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29892665 | 0.82 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021452-B1 | SUBSTITUTED (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO COMPOUNDS USEFUL AS JAK1 INHIBITORS | CHEMWERTH INC (US) | 2023-12-20 | — | — | EP | disclosed |