⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19748065 | 0.71 | — | — | |
| SCHEMBL30782082 | 0.68 | EPHX1 (0.31) | — | |
| SCHEMBL30782096 | 0.64 | — | — | |
| SCHEMBL24423999 | 0.62 | — | — | |
| SCHEMBL22585266 | 0.62 | EPHX1 (0.30) | — | |
| SCHEMBL22585247 | 0.62 | EPHX1 (0.30) | — | |
| SCHEMBL25433101 | 0.62 | — | — | |
| SCHEMBL31298327 | 0.62 | EPHX1 (0.30) | — | |
| SCHEMBL19766633 | 0.60 | EPHX1 (0.32) | — | |
| SCHEMBL20934668 | 0.60 | ASGR1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327412-A1 | FACTOR XIIA INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2024-10-03 | — | — | US | disclosed |
| EP-4294798-A1 | FACTOR XIIA INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022175675-A1 | FACTOR XIIA INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-08-25 | — | — | WO | disclosed |