Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26973703 | 0.91 | GRIN2D (0.50) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973690 | 0.89 | GRIN2D (0.49) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973698 | 0.89 | GRIN2D (0.46) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973699 | 0.89 | GRIN2D (0.46) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973691 | 0.88 | ALDH1A1 (0.56) | RRM1ALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL26973695 | 0.87 | HSD17B2 (0.46) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973709 | 0.85 | GRIN2D (0.46) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973692 | 0.85 | MEN1 (0.49) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL26973710 | 0.85 | GRIN2D (0.43) | RRM1ALDH1A1POLBGRIN2DGRIN3B | |
| SCHEMBL24175847 | 0.85 | KDM4E (0.58) | RRM1ALDH1A1POLBLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858879-B2 | PARG inhibitors and method of use thereof | CITY OF HOPE (US) | 2024-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858879-B2 | PARG inhibitors and method of use thereof | PARG, PARP12, PARP15 | RRM1 658/4885ALDH1A1 1104/4885POLB 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.