Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977084 | 0.85 | CLK1 (0.40) | HTTSYKCHRM4GRM5GRM1 | |
| SCHEMBL26976968 | 0.82 | HTT (0.51) | HTTALDH1A1SMN1; SMN2SYKGRIN2B | |
| SCHEMBL20582169 | 0.81 | HTT (0.60) | HTTPIK3CAMTORALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL20582301 | 0.80 | HTT (0.59) | HTTPIK3CAMTORALDH1A1SMN1; SMN2 | |
| SCHEMBL21980140 | 0.78 | HTT (0.56) | HTTSYKCHRM4CHRM2CYP2D6 | |
| Hydrochloric Acid SCHEMBL21980201 | 0.77 | HTT (0.55) | HTTALDH1A1SMN1; SMN2SYKCHRM4 | |
| SCHEMBL26977098 | 0.74 | HTT (0.39) | HTTPIK3CAMTORALDH1A1SMN1; SMN2 | |
| SCHEMBL16338768 | 0.72 | HTT (0.66) | HTTMTORSYK | |
| SCHEMBL26977191 | 0.71 | GRM5 (0.40) | HTTGRM5GRM1 | |
| SCHEMBL26976857 | 0.71 | HTR2A (0.45) | MTORALDH1A1DRD2SLC6A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634953-B1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-01-03 | — | — | EP | claimed |