Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 7/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26976968 | 0.90 | HTT (0.51) | GRM5GRM1HTTMAT2ABRD4 | |
| SCHEMBL26976934 | 0.88 | TLR8 (0.40) | GRM5GRM1MAT2ACLK1CLK2 | |
| SCHEMBL21979906 | 0.83 | HTT (0.43) | GRM5GRM1HTTMAT2ADYRK1A | |
| Hydrochloric Acid SCHEMBL21980096 | 0.82 | HTT (0.43) | GRM5GRM1HTTMAT2ADYRK1A | |
| SCHEMBL7499536 | 0.74 | BRD4 (0.41) | GRM5GRM1HTTMAT2ABRD4 | |
| SCHEMBL26977043 | 0.74 | TLR8 (0.46) | CLK1CLK2DYRK1AHIPK1HIPK2 | |
| SCHEMBL26976948 | 0.73 | MAT2A (0.40) | GRM5GRM1HTTMAT2ACLK1 | |
| SCHEMBL21980140 | 0.73 | HTT (0.56) | GRM5GRM1HTTMAT2ADYRK1A | |
| Hydrochloric Acid SCHEMBL21980201 | 0.72 | HTT (0.55) | GRM5GRM1HTTMAT2ADYRK1A | |
| SCHEMBL26977015 | 0.71 | HTT (0.53) | GRM5GRM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634953-B1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-01-03 | — | — | EP | claimed |