SCHEMBL26979660

SCHEMBL26979660

O=C(O)NCCCCCCCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.72

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 10/20 0.72
▸ DDB1 Q16531 8/20 0.72
▸ STAT3 P40763 2/20 0.71
▸ HDAC1 Q13547 5/20 0.70
▸ HDAC6 Q9UBN7 5/20 0.70
▸ HDAC3 O15379 2/20 0.70
▸ HDAC2 Q92769 2/20 0.70
▸ HDAC4 P56524 1/20 0.70
▸ NCOR2 Q9Y618 1/20 0.70
▸ GSK3B P49841 2/20 0.59
▸ PIP4K2C Q8TBX8 1/20 0.58
▸ BRD4 O60885 4/20 0.58
▸ TRIM24 O15164 3/20 0.58
▸ TRIM33 Q9UPN9 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23884221 1.00 CRBN (0.72) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL17839888 1.00 CRBN (0.72) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL17839981 1.00 CRBN (0.72) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL17839732 0.96 CRBN (0.76) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL26320196 0.96 STAT3 (0.76) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL19612064 0.95 CRBN (0.65) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL17873761 0.95 CRBN (0.70) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL17839764 0.94 CRBN (0.69) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL19612039 0.94 CRBN (0.66) CRBNDDB1STAT3HDAC1HDAC6
SCHEMBL24391031 0.94 STAT3 (0.72) CRBNDDB1STAT3HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240002360-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2024-01-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240002360-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 CRBN 235/4885DDB1 2244/4885STAT3 2944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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